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Leo Dog

Disease Screening

Scientific Legacy

Multi-drug Sensitivity – MDR1

MDR1 or Multi-drug Resistance 1 is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed-breed dogs. This mutation can have a significant impact on drug sensitivity. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care. To learn more about specific drugs and breeds most commenly affected by MDR1, visit the Wisdom Panel 3.0 product page here.

Technology Licensed By

The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test that has been licensed exclusively to Wisdom Health in the United States for use in the Wisdom Panel tests.